Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus.

Fabiana Galland,Elisa Negri, Carollina Da Ré,Fernanda Fróes,Liliane Strapazzon,Maria Cristina Guerra,Lucas Silva Tortorelli,Carlos-Alberto Gonçalves,Marina Concli Leite

NeuroToxicology（2017）

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摘要

•BDNF is reduced in hippocampus under ammonia toxicity.•Astrocytes play an important role in BDNF secretion.•Glutamine–glutamate cycle is compromised in hyperammonemia in hippocampus.

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关键词

ALT,AST,BDNF,CNS,CSF,GFAP,GS,GSH,HE,LDH,NMDA,MTT,UIH

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