Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation.

Wenjing Li,Ting Liu,Yingluo Xiong,Jiaoyan Lv,Xinyi Cui,Rui He

Cytokine（2018）

引用 11|浏览5

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摘要

•DEP exposure induced LTB4 production and neutrophils infiltration and promoted lung metastasis of 3LL or 4T1 tumor cells.•BLT1 blockade attenuated DEP-induced neutrophilic lung inflammation.•BLT1 blockade before inflammation onset, but not after tumor cell seeding inhibited DEP-enhanced lung metastasis.•BLT2 blockade failed to inhibit DEP-induced lung inflammation and tumor metastasis.

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关键词

Diesel exhaust particle,Leukotriene B4-BLT1 axis,Neutrophil,Lung inflammation,Metastasis

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