FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer.

•FGF-2 drives both numerical and structural chromosomal instability in prostate cancer cells.•A high stromal FGF-2 expression is associated with adverse clinico-pathological features.•The tumor stroma can shape prostate cancer cell genomes and is hence a promising new source for prognostic biomarkers and drug targets.