3'-Modification stabilizes mRNA and increases translation in cells.

Christian Gampe, Amy C Seila White,Swetha Siva,Frédéric Zécri,John Diener

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•3′-Modified RNAs were synthesized in synthetically useful yields.•These RNAs showed increased stability toward exonuclease degradation.•3′-Modification resulted in increased and extended mRNA expression in cells.•This method may facilitate the development of mRNA gene therapy.

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关键词

mRNA,3′-Terminus,Translation,Gene therapy,Bioconjugation,Nucleotide

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