Early Fibrinogen Concentrate Therapy for Major Haemorrhage in Trauma (E-FIT 1): Results from a UK Multi-Centre, Randomised, Double Blind, Placebo-Controlled Pilot Trial
Critical care(2018)
摘要
There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial, we explored the use of fibrinogen concentrate, which may have advantages of more rapid administration in acute haemorrhage. The aims of this pragmatic study were to assess the feasibility of fibrinogen concentrate administration within 45 minutes of hospital admission and to quantify efficacy in maintaining fibrinogen levels ≥ 2 g/L during active haemorrhage.
更多查看译文
关键词
Fibrinogen replacement therapy,Haemorrhagic shock,Multiple trauma,Cryoprecipitate,Transfusion
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要