Lacosamide efficacy and tolerability in clinical practice - Post marketing analysis from a single dedicated epilepsy center.

Mark D Baker,Bassel W Abou-Khalil,Amir Arain,Pavan Tummala,Nabil J Azar,Kevin F Haas,Hasan H Sonmezturk

Clinical Neurology and Neurosurgery（2018）

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摘要

•Patients were more likely to continue LCM with titration rate >4 weeks.•Patients reported fewer AEs when LCM was titrated over >4 weeks.•AEs were more common when LCM added to Na-channel blocking AEDs.•Discontinuation was more common when LCM added to Na-channel blocking AEDs.•LCM achieved greater seizure freedom rate in clinical practice compared to pivotal trials.

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关键词

Lacosamide,Efficacy,Tolerability,Post-marketing,Analysis

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