Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1ß

Dhemerson Souza de Lima,Vinicius C.L. Nunes,Mauricio M. Ogusku,Aya Sadahiro,Alessandra Pontillo,Bruna de Cunha Alencar

Infection, Genetics and Evolution（2017）

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摘要

Siglec-1/CD169 is a sialoadhesin expressed by macrophages thought to function in cell-to-cell interactions. In the lung, the expression of Siglec-1 is specific for alveolar macrophages and single nucleotide polymorphisms (SNPs) in SIGLEC1 have been recently associated with asthma severity.

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关键词

Tuberculosis,SIGLEC1/CD169,SNPs,IL-1ß

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