Parp1 Inhibitor Eliminated Imatinib-Refractory Chronic Myeloid Leukemia Cells In Bone Marrow Microenvironment Conditions

Paulina Podszywalow-Bartnicka,Silvia Maifrede,Bac Viet Le,Margaret Nieborowska-Skorska,Katarzyna Piwocka,Tomasz Skorski

LEUKEMIA & LYMPHOMA（2019）

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摘要

Treatment with tyrosine kinase inhibitors (TKIs) results in remission and prolongation of survival, but fails to eliminate the leukemia stem cells (LSCs) responsible for disease development and pro...

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关键词

chronic myeloid leukemia cells,parp1 inhibitor,bone marrow,imatinib-refractory

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