G-quadruplex DNA targeting alters class-switch recombination in B cells and attenuates allergic inflammation

Zeinab Dalloul,Pauline Chenuet,Iman Dalloul,Francois Boyer,Jean-Claude Aldigier,Brice Laffleur,Yolla El Makhour,Bernhard Ryffel,Valerie F. J. Quesniaux,Dieudonnee Togbe,Jean-Louis Mergny,Jeanne Cook-Moreau,Michel Cogne

Journal of Allergy and Clinical Immunology（2018）

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摘要

Targeting immunoglobulin switch regions with a G4-DNA binding drug offers a novel immunomodulatory strategy reducing class-switched antibody secretion.

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关键词

Allergic asthma model,B lymphocytes,G-quadruplex,immunoglobulin class switch,immunopathology

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