Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease.

Lauren A Shreve,Anca Velisar,Mahsa Malekmohammadi,Mandy Miller Koop,Megan Trager,Emma J Quinn,Bruce C Hill,Zack Blumenfeld,Camilla Kilbane,Alessandra Mantovani,Jaimie M Henderson,Helen Brontë-Stewart

Clinical Neurophysiology（2017）

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摘要

•Parkinson’s neural oscillations and coupling were greater in the more affected STN and were evident in 98% cases.•Positive correlation between frequencies of beta and HFO at maximum PAC strength.•Alpha/beta band power was lower in the tremor dominant phenotype and was attenuated by emergent tremor.

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关键词

Parkinson’s disease,Beta oscillations,Tremor,Phase amplitude coupling,Deep brain stimulation,Phenotypes

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