Vitamin E and vitamin C attenuate Di-(2-ethylhexyl) phthalate-induced blood-testis barrier disruption by p38 MAPK in immature SD rats

Lianju Shen,Xiangliang Tang,Yi Wei,Chunlan Long,Bin Tan,Shengde Wu,Mang Sun,Yue Zhou,Xining Cao,Guanghui Wei

Reproductive Toxicology（2018）

引用 44|浏览3

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摘要

•DEHP induced BTB integrity disruption through activating p38 MAPK signaling pathway.•In the process of DEHP induced BTB integrity impairment, oxidative stress is the initiating factor.•Antioxidants—vitamin E and C can rescue BTB integrity disruption induced by DEHP.

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关键词

DEHP,Sertoli cell,BTB,Oxidative stress,p38

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