Emerging technologies for prediction of drug candidate efficacy in the preclinical pipeline.
Drug Discovery Today(2017)
摘要
•Patient-on-a-chip systems recapitulate genetics and physiology of human patients.•Light-sheet microscopy enables time-resolved 3D imaging of in vitro systems.•Image-based modeling enables reconstruction of mechanistic models from imaging data.•Drug candidate efficacy and safety are assessed with image-based model for pathophysiology.
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