Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786

A new azaphilone derivative, named peniazaphilin A ( 1 ) and one known isocoumarin, ( R )-3-methyl-6-hydroxy-8-methoxy-3,4-dihydroisocoumarin ( 2 ) were isolated from the fungus Penicillium sp. CPCC 400786. Their structures were elucidated by means of extensive spectroscopic analysis. The absolute configuration of 2 was established by circular dichroism for the first time. Compounds 1 and 2 exhibited weak anti-HIV activities with the IC 50 values of 60.4 and 69.3 μM, respectively.