Diet induced obesity modifies vitamin D metabolism and adipose tissue storage in mice.

Lauriane Bonnet, Mohammed Amine Hachemi,Esma Karkeni,Charlene Couturier,Julien Astier,Catherine Defoort,Ljubica Svilar,Jean-Charles Martin,Franck Tourniaire,Jean-François Landrier

The Journal of Steroid Biochemistry and Molecular Biology（2019）

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摘要

•Diet induced obesity modifies the transcription of vitamin D metabolism enzymes in mice adipose tissue.•Such modifications are associated to a decrease of free 25(OH)D in plasma and an increase of 25(OH)D in adipose tissue.•Impact of diet-induced obesity on adipose tissue biology could contribute to the obesity-related reduction of free 25(OH)D.

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关键词

Obesity,High fat diet,Vitamin D,Metabolism,Adipose tissue,Free 25-hydroxyvitamin D

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