Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.

Jolanta Bratosiewicz-Wasik,Pawel P Liberski,Beata Peplonska,Maria Styczynska,Joanna Smolen-Dzirba,Mariusz Cycon,Tomasz J Wasik

Neuroscience Letters（2018）

引用 7|浏览22

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摘要

•The relationship between APOE -491 A/T, -427C/T, and −219 T/G SNP and AD was studied.•The −491 T allele and the −491 A/T genotype protect against AD.•The −219 T/G heterozygosity is a potential risk factor of AD.

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关键词

Alzheimer’s disease,Apolipoprotein E,APOE promoter,Single nucleotide polymorphism

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