AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.

Luke J Alderwick,Helen L Birch,Karin Krumbach,Michael Bott,Lothar Eggeling,Gurdyal S Besra

The Cell Surface（2018）

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摘要

•Generation of a single aftD and double aftB/aftD mutants in C. glutamicum.•Phenotypic analysis of purified cell wall material indicates a cell wall lesion.•Cell free biochemical assays indicate AftD functions as an α(1 → 5) AraT.

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关键词

Corynebacterium glutamicum,Mycobacterium tuberculosis,Cell wall,Arabinogalactan,Glycosyltransferase

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AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.

AftD functions as an α1 → 5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core.