Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Carbapenemase-Producing .

Anubhav Kanwar,Steven H Marshall,Federico Perez, Myreen Tomas,Michael R Jacobs,Andrea M Hujer,T Nicholas Domitrovic,Susan D Rudin,Laura J Rojas,Barry N Kreiswirth,Liang Chen,Miguel Quinones-Mateu,David van Duin,Robert A Bonomo

OPEN FORUM INFECTIOUS DISEASES（2018）

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摘要

We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

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关键词

carbapenemase,colistin resistance,Klebsiella pneumoniae

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