Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota.

Julie A K McDonald,Benjamin H Mullish,Alexandros Pechlivanis,Zhigang Liu,Jerusa Brignardello,Dina Kao,Elaine Holmes,Jia V Li,Thomas B Clarke,Mark R Thursz,Julian R Marchesi

Gastroenterology（2018）

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摘要

We identified valerate as a metabolite that is depleted with clindamycin and only recovered with FMT. Valerate is a target for a rationally designed recurrent CDI therapy.

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关键词

Bacteria,Stool Transplant,Gut Microbiome,Pathogen

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