Adhesion and stiffness of biotin-superavidin bonds.

Bahman Farzi,Jan Scrimgeour,Cetin Cetinkaya

Colloids and Surfaces B: Biointerfaces（2018）

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摘要

•SAv-Bi bonds and PEG polymers are common in pharmaceutical applications.•A non-invasive vibrational spectroscopy technique is introduced.•This approach provides a direct non-contact measurement technique.•The average spring constant of an individual SAv-Bi.PEG bond is 0.1-0.4 mN/m.•The work-of-adhesion is determined to be 0.54–2.62 J/m2.

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关键词

Molecular adhesion,Surface energy,Biotin-superavidin bonds,Bond stiffness,Ultrasonic excitation,Laser Doppler vibrometry

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