An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

Jason M Gehrke,Oliver Cervantes,M Kendell Clement,Yuxuan Wu,Jing Zeng,Daniel E Bauer,Luca Pinello,J Keith Joung

NATURE BIOTECHNOLOGY（2018）

引用 322|浏览7

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摘要

The precision of base editing is enhanced with an engineered version of the APOBEC3A deaminase.

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关键词

Molecular biology,Molecular engineering,Targeted gene repair,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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