Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment.

Diego Tosi,Esther Pérez-Gracia, Salima Atis,Nadia Vié,Eve Combès, Mélissa Gabanou,Christel Larbouret,Marta Jarlier,Caroline Mollevi,Adeline Torro,Maguy Del Rio,Pierre Martineau,Céline Gongora

BMC cancer（2018）

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摘要

Analysis of chemotherapy-induced phosphokinome changes helps to elucidate the mechanisms of drug resistance and to guide the selection of targets for combination therapies with synergistic activity.

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关键词

Colorectal cancer,Drug combinations,Phosphokinome,Irinotecan,Synergistic effect

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