Deletion of the ORF2 Gene of the Neuropathogenic Equine Herpesvirus Type 1 Strain Ab4 Reduces Virulence While Maintaining Strong Immunogenicity

Christiane L. Schnabel,Christine L. Wimer,Gillian Perkins,Susanna Babasyan,Heather Freer, Christina Watts,Alicia Rollins,Nikolaus Osterrieder,Bettina Wagner

BMC veterinary research（2018）

引用 18|浏览22

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摘要

Equine herpesvirus type 1 (EHV-1) induces respiratory infection, abortion, and neurologic disease with significant impact. Virulence factors contributing to infection and immune evasion are of particular interest. A potential virulence factor of the neuropathogenic EHV-1 strain Ab4 is ORF2.

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关键词

Horse,EHV-1,ORF2,Virulence factor,Immunoglobulin,Mucosal immune response

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