Pro-inflammatory immune-to-brain signaling is involved in neuroendocrine responses to acute emotional stress.

Jordi Serrats,Jan-Sebastian Grigoleit,Elena Alvarez-Salas,Paul E Sawchenko

Brain, Behavior, and Immunity（2017）

引用 18|浏览24

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摘要

•Inflammatory contributions of perivascular macrophages (PVMs) to CNS responses to non-inflammatory stress.•Acute restraint stress activates brain PVM (COX-2, PGE2) inflammatory responses.•Indomethacin (icv or iv) or PVM ablation blocks hypothalamic response to restraint.•Ablation of brain PVMs reduces restraint-induced stress hormone secretion.

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关键词

Clodronate liposomes,Cyclooxygenase,Hypothalamo-pituitary-adrenal axis,Paraventricular nucleus,Perivascular macrophage,Prostaglandin E2,Restraint,Stress

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