All on one high-performance thin-layer chromatography plate: solvent-free nanomole-scaled on-surface synthesis, workup and online high-resolution mass spectrometry for elucidation of two new degradation products in an ifosfamide formulation.

Journal of Chromatography A（2018）

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摘要

•Using HPTLC plates for solvent-free nanomole-scaled on-surface synthesis.•Miniaturized synthesis, workup and analysis performed on one HPTLC plate.•Tool for rapid impurity analysis of an anti-cancer drug.•On-surface synthesis enabled impurity signal highlighting in HPTLC-HRMS.

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关键词

Structure elucidation,On-surface synthesis,Ifosfamide,Green analytical chemistry,Impurity analysis

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