Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.

Csaba Orbán,Zsófia Vásárhelyi,Anna Bajnok,Florentina Sava,Gergely Toldi

Immunobiology（2018）

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摘要

Caffeine and selective PDE inhibitors are widely used in clinical management of preterm and term neonates. However, little is known about how these compounds interact with the neonatal adaptive immune system. We aimed to describe the effects of caffeine, milrinone and sildenafil on the activation and cytokine production of T cells from umbilical cord blood (UCB) compared to adult peripheral blood (APB).

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关键词

APB,AR,au,AUC,cAMP,DHE,ER,IFN-γ,IL,NFAT,PDE,PHA,ROS,RyR,SOCE,UCB

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