A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN.

Subhashree Devasenapathy,Rashi Midha,Teesta Naskar,Anuradha Mehta,Bharat Prajapati, Mariam Ummekulsum,Rajesh Sagar,Nandini C Singh,Subrata Sinha

Asian Journal of Psychiatry（2018）

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摘要

•First report of role of variations in RELN signalling pathway genes in dyslexia.•Seven assayed SNPs across RELN showed association in the multimarker tests.•Tri-allelic unit TAT (rs3808039, rs2072403, rs362746) overtransmitted to dyslexics.•We propose RELN as a novel candidate locus for dyslexia.

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DSM-IV,GIH,BEB,ITU,PJL,HBAT,FBAT,LD,SNP,NCR,L1 and L2,MAF

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