T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.

•The intestinal T1R2 receptor enhances glucose absorption in vivo and ex vivo.•Pharmacological inhibition of STRs reduces glucose flux in human intestinal preparations.•T1R2 regulates glucose absorption dependent on GLUT2 activity in enterocytes.•GLP-2 mediates the effects of T1R2 signaling through activation of enteric neurons.•High sucrose diet rapidly downregulates STRs leading to reduced glucose absorption.