Chrome Extension
WeChat Mini Program
Use on ChatGLM

Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects.

NANOMEDICINE(2018)

Cited 5|Views17
No score
Abstract
Aim: To investigate the possible mechanisms of telomerase and telomere underlying the anticancer effects of silver nanoparticles (AgNPs). Materials & methods: 25nm polyvinylpyrrolidone-coated AgNPs were used. The telomerase activity and telomere function were evaluated. The anticancer effects of AgNPs were gauged with cell viability assay under different statement of telomerase and telomere. Results & conclusion: AgNPs could inhibit telomerase activity and lead to telomere shortening and dysfunction. Overexpression of telomerase attenuated the anticancer activity of AgNPs, whereas downregulation of telomerase activity or dysfunction of the telomere enhanced the cytotoxicity of AgNPs in HeLa cells. Our findings provided strong evidence that the anticancer effects of AgNPs were mediated via interference with the telomerase/telomere.
More
Translated text
Key words
anticancer effects,radiosensitivity,silver nanoparticles,telomerase,telomere
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined