Vitamin E-based redox-sensitive salinomycin prodrug-nanosystem with paclitaxel loaded for cancer targeted and combined chemotherapy.
Colloids and Surfaces B: Biointerfaces(2018)
摘要
•The TS prodrug conjugates were designed by covalently coupling the lipophilic TOS moiety to SAL via disulfide linkages.•The TS prodrug conjugates were readily self-aggregated into stable nanoparticles.•The TS prodrug nanoparticles were tumor-targeting and glutathione-sensitive.•The TS prodrug nanoparticles were designed for synergistic salinomycin-paclitaxel combination chemotherapy.
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关键词
D-α-tocopheryl succinate,Salinomycin,Prodrug nanoparticles,Tumor targeting,Combined chemotherapy
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