Age-Related Chromosomal Aberrations In Patients With Diffuse Large B-Cell Lymphoma: An In Silico Approach

Background: In diffuse large B-cell lymphoma (DLBCL), chromosomal aberrations are known to increase with advancing age. Our study aims to determine if there are other genetic aberrations associated with DLBCL based on age.Methods: Using the Mitelman Database of Genetic Aberrations, we were able to find 749 cases of DLBCL with genomic aberrations with a median age of 62 years. Patients with DLBCL chromosomal aberration analysis results were divided into four groups based on age (0 - 30, 31- 50, 51- 70, > 71 years) and examined by chi-square analysis and Mantel-Cox for survival analysis.Results: Ten aberrations were found to be significant with a particular age range: t(2;3), trisomy 19p13, trisomy 18q21, trisomy 3, trisomy 7, trisomy 14, trisomy 16, trisomy 18, monosomy 3 and monosomy 11, and survival ranged from 7 to 25 months.Conclusion: This suggests that patients with DLBCL are likely to accumulate specific translocations depending on their age at the onset of DI,BCL.