CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis.

Haixu Song,Chenghui Yan,Xiaoxiang Tian,Nan Zhu,Yang Li,Dan Liu,Yanxia Liu,Meili Liu,Chengfei Peng,Quanyu Zhang,Erhe Gao,Yaling Han

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2017）

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摘要

•CREG mitigates infarction and improves cardiac function induced by MI/R injury.•CREG plays an important role in anti-apoptosis of cardiomyocytes.•CREG activates lysosomal autophagy to protect heart from MI/R injury.

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关键词

CREG,Ischemia/reperfusion injury,Cardiac function,Apoptosis,Autophagy,Lysosome

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