A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.

Haruchika Yamamoto,Seiichiro Sugimoto,Shin Tanaka,Takeshi Kurosaki,Shinji Otani,Masaomi Yamane,Naruto Taira,Takahiro Oto,Shinichi Toyooka

Surgery today（2019）

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摘要

The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.

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关键词

Chronic lung allograft dysfunction,Glucocorticoid,Lung transplantation,Single-nucleotide polymorphism,Total lung capacity

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