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Nuclear envelope assembly defects link mitotic errors to chromothripsis.

MOLECULAR BIOLOGY OF THE CELL, no. 26 (2018): 551-555

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Defects in the architecture or integrity of the nuclear envelope are associated with a variety of human diseases. Micronuclei, one common nuclear aberration, are an origin for chromothripsis, a catastrophic mutational process that is commonly observed in cancer. Chromothripsis occurs after micronuclei spontaneously lose nuclear envelope i...更多

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作者
Shiwei Liu
Shiwei Liu
Mark Mannino
Mark Mannino
Nachen Yang
Nachen Yang
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