Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol 2 .
The Journal of Steroid Biochemistry and Molecular Biology(2019)
摘要
•A convergent synthesis of the 28,28,28-trideutero-25-hydroxydihydrotachysterol2 was achieved.•Isotope labeling was introduced through a syn-SN2’ allylic substituton with lithium deuterocuprate.•The construction/formation of the diene system was done by the Wittig-Horner approach.•28,28,28-Trideutero-25-hydroxydihydrotachysterol2 has been used as a internal standard for HPLC/MS.
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关键词
25-Hydroxydihydrotachysterol2,Labeled compounds,Vitamin D,Synthesis
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