Assessment of the impact of manufacturing changes on the physicochemical properties of the recombinant vaccine carrier ExoProtein A.

Martin Burkhardt,Karine Reiter,Vu Nguyen,Motoshi Suzuki,Raul Herrera,Patrick E Duffy,Richard Shimp,Nicholas J MacDonald, L Renee Olano,David L Narum

Vaccine（2019）

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摘要

•ExoProtein A is a carrier protein for conjugate vaccines.•Improved purification process yields comparable quantity of bulk EPA.•Improved purification process yields bulk EPA with a better purity profile.•Immunogenicity of EPA derived original and improved process appear highly similar.

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关键词

Vaccine,Vaccine carrier,Malaria,Host cell protein,Mass spectrometry,ExoProtein A,Purification,Mixed-mode chromatography

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