Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B E Antigen in Individuals with Chronic Hepatitis B Virus Infection.

Jessica Liu,Hui-Han Hu,Chia-Ling Chang,Chin-Lan Jen,Mei-Hsuan Lee,Sheng-Nan Lu,Li-Yu Wang,Quan Yuan,Ning-Shao Xia,Masaya Sugiyama,Nao Nishida,Masashi Mizokami,Chien-Jen Chen,Pei-Jer Chen,Hwai-I Yang

Clinical gastroenterology and hepatology the official clinical practice journal of the American Gastroenterological Association（2018）

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摘要

For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2.

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