Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold.

Maria Digiacomo,Stefania Sartini,Giulia Nesi,Simona Sestito,Vito Coviello,Concettina La Motta,Simona Rapposelli

The open medicinal chemistry journal（2017）

引用 3|浏览11

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摘要

Although further substitution patterns are needed, the novel compounds here proposed represent a good starting point for the development of novel and effective ARIs.

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关键词

ARL2,Aldose reductase enzyme,Aldose reductase inhibitors (ARI),Diabetic complications,Spiro-oxazolidinones,Spirobenzopyran derivatives,Spiromorpholinone derivatives

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