Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects.

Background. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results. After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (p < 0.001) and Actinobacteria (p < 0.001) and a significant increase in Bacteroidetes (p < 0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (p < 0.05), gas (p = 0.035), and abdominal pain (p = 0.015) as well as significant improvements in stool consistency (p < 0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (p = 0.107). The supplement was safe and well tolerated. Conclusions. The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.