A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo.

Xiaole Cui,Yanhong Ji,Zhengxiang Wang,Yingying Du, Haoran Guo,Liang Wang,Hualan Chen,Qiyun Zhu

Veterinary Microbiology（2018）

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摘要

•Replication of H5N6 AIV with a 113-aa truncated NS1 was attenuated in cells.•The 113-aa truncated NS1 impaired the inhibition of IFN induction in vitro.•The 113-aa truncated NS1 enhanced cellular apoptosis in vitro.•Replication of H5N6 AIV with a 113-aa truncated NS1 was attenuated in chickens.

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关键词

H5N6 AIV,NS1,Replication,Interferon,Apoptosis

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