Mononuclear phagocyte system function and nanoparticle pharmacology in obese and normal weight ovarian and endometrial cancer patients.

Brittney R Starling,Parag Kumar,Andrew T Lucas,David Barrow,Laura Farnan,Laura Hendrix,Hugh Giovinazzo,Gina Song,Paola Gehrig,Jeannette T Bensen,William C Zamboni

Cancer chemotherapy and pharmacology（2019）

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摘要

Higher MPS function resulting in reduced PLD exposure is a potential mechanism for reduced efficacy of PLD and other nanoparticles observed in obese patients with cancer. PK simulations suggest higher doses of PLD are required in obese patients to achieve similar exposures as standard dosing in normal weight patients.

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关键词

Nanoparticle,Pharmacology,Obesity,Ovarian cancer,Endometrial cancer,Estradiol

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