Changes And Correlations Of Serum Interleukins, Adhesion Molecules And Soluble E-Selectin In Children With Allergic Rhinitis And Asthma

Objective: To observe the changes and correlations of serum interleukins (ILs), adhesion molecules and soluble E-selectin (sE-selectin) in children with allergic rhinitis, asthma and both diseases.Methods: A total of 45 children with allergic rhinitis, 40 with asthma and 45 with allergic rhinitis complicated with asthma treated from September 2016 to January 2018 were selected. Meanwhile, 30 healthy subjects who received physical examinations were included as a control group. The levels of serum IL-4, IL-5, IL-10, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), and sE-selectin were detected by double-antibody sandwich ELISA, and their correlations were subjected to Spearman's correlation analysis.Results: The serum IL levels of allergic rhinitis, asthma and complication groups were significantly higher than those of control group (P<0.01), and the levels of complication group significantly exceeded those of asthma group (P<0.05). The serum levels of IL-5 and IL-10 in complication group significantly exceeded those of allergic rhinitis group (P<0.05). Compared with control group, serum sICAM-1, sVCAM-1, and sE-selectin levels significantly increased in other three groups (P<0.01). Such levels of complication group were significantly higher than those of allergic rhinitis and asthma groups (P<0.05). Serum IL-10 level was positively correlated with that of IL-4 (r=0.965, P<0.05), and sE-selectin level was positively correlated with those of sICAM-1 and sVCAM-1 (r=0.915, P<0.01; r=0.892, P<0.01).Conclusion: Serum IL-4, IL-5, IL-10, adhesion molecules and sE-selectin are all involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases.