Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function.

Ijeoma M Muo,Sung-Jun Park, Antoine Smith,Danielle A Springer,Michele D Allen,Timothy J Hagen,Jay H Chung

Biochemical and Biophysical Research Communications（2018）

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摘要

•Seven weeks of Compound D159687 (D159687) induces weight loss in aged mice.•D159687 causes a selective loss of fat mass while preserving lean mass.•The weight loss in D159687 treated mice occurred despite increased food intake.

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关键词

Obesity,Aging,Calorie restriction,AMPK,Phosphodiesterase

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