Acyl-CoA Synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression.

Ulises Daniel Orlando,Ana Fernanda Castillo, Mayra Agustina Ríos Medrano,Angela Rosaria Solano,Paula Mariana Maloberti,Ernesto Jorge Podesta

Biochemical Pharmacology（2019）

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摘要

Acyl-CoA synthetase-4 (ACSL4) is an enzyme implicated in estrogen receptor α (ERα) negative regulation and hormone therapy resistance in breast cancer. In addition, ACSL4 has been associated to certain types of hormone resistance in prostate cancer.

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关键词

ACSL4,MBC,ER,Tet,ABC,shRNA,BrdU,MTT,qRT-PCR,ERBB2,PGE2,mTORC1/2,p70S6K,Rictor,GSK3 α/β

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