Cannabinoid type 2 (CB2) receptor system modulates paclitaxel-induced microglial dysregulation and central sensitization in rats.

Jiang Wu, Mark Hocevar,Bihua Bie,Joseph F Foss,Mohamed Naguib

The Journal of Pain（2019）

引用 52|浏览1

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摘要

•MDA7 (1-([3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl] carbonyl) piperidine) modulated microglial expression of cytokines induced by paclitaxel.•MDA7 modulated epigenetic upregulation of microglial brain-derived neurotrophic factor (BDNF) induced by paclitaxel.•BDNF regulated glutamatergic and GABAergic transmission in dorsal horn.•MDA7 (cannabinoid type 2 [CB2] agonist) attenuated paclitaxel-induced molecular and behavioral changes.

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关键词

Paclitaxel,cannabinoid type 2 (CB2) receptor,microglia,neuropathic pain,neuroinflammation

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