A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.

Andrew J Kwilasz,Suzanne M Green Fulgham,Amanda Ellis,Hardik P Patel,Julissa Chante Duran-Malle,Jacob Favret,Lewis O Harvey,Jayson Rieger,Steven F Maier,Linda R Watkins

Brain, Behavior, and Immunity（2019）

引用 12|浏览6

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摘要

•Prior work showed that intrathecal A2a agonists produced long term pain suppression.•This study explores efficacy of the A2a agonist ATL313 at the site of nerve injury.•A single peri-sciatic ATL313 dose created long-term suppression of neuropathic pain.•Pain suppression correlated with decreased sciatic nerve inflammatory markers.

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关键词

Adenosine 2A receptor,Sciatic nerve,Mechanical allodynia,Inflammation,Rat,Interleukin-1beta,Nitric oxide,GFAP,Iba1,iNOS,Neuropathy,Neuroinflammation

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