Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases.

•CYP1A2/2C19/2E1/3 A4 and UGT1A1/1A6/2B7 may be involved in the metabolism of RA.•UGTs have higher capacity and lower affinity for RA metabolism than phase I enzymes.•RA inhibits CYP2C19 via a mixed mechanism.•RA inhibits CYP2E1 and UGT1A1/1A6/2B7 via a competitive mechanism.