The effect of high glucose-based peritoneal dialysis fluids on thioredoxin-interacting protein expression in human peritoneal mesothelial cells

Jun Wu,Yun-Fang Zhang,Ju-Shuang Li,Ge-Li Zhu,Zhi-Min Bi,Xiang-You Li

International Immunopharmacology（2019）

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摘要

•High glucose-based peritoneal dialysis (PD) fluids upregulate TXNIP expression in vitro and in vivo.•High glucose-based PD fluids disrupt TRX1-TXNIP association and enhance TXNIP-NLRP3 interaction.•Inhibition of ROS blocks TXNIP-NLRP3 binding and decreases IL-1β expression induced by high glucose-based PD fluids.

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关键词

High glucose-based peritoneal dialysis fluids,Peritoneal mesothelial cells,Thioredoxin-interacting protein,NACHT, LRR and PYD domains-containing protein 3,Reactive oxygen species,Inflammation

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