Personalized conciliation of clinical guidelines for comorbid patients through multi-agent planning.

•Multi-Agent Planning (MAP) enables the design of decision support systems for comorbidity.•Single-disease specialist agents coordinate to conciliate CIGs and cooperate to plan a common treatment.•Patient Empowerment by accounting for patient's preferences in personalized conciliated plans.•Most relevant interactions arising in comorbidity settings when conciliating CIGs are solved.•Equipoise situations are addressed by considering patient/institutional preferences.