The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

Fabian Christoph Franke,Johannes Müller,Miguel Abal,Eduardo Domínguez Medina,Ulrich Nitsche,Henri Weidmann,Solenne Chardonnet,Ewa Ninio,Klaus-Peter Janssen

Cellular and Molecular Gastroenterology and Hepatology（2019）

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摘要

We propose SASH1 as an inhibitor of CRKL-mediated SRC signaling, introducing a potentially druggable mechanism counteracting chemoresistance and metastasis formation.

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关键词

EMT,Tumor Suppressor,SRC-Kinase,Chemoresistance

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