Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage.

Shuzo Yamamoto,Tatsushi Mutoh,Kazumasu Sasaki,Tomoko Mutoh,Yasuyuki Taki

Brain Research Bulletin（2019）

引用 6|浏览4

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摘要

•Rapamycin exerts neuroprotectiosn against EBI early after murine SAH.•Central rapamycin microinjection improved post-SAH CBF, SbtO2, and CO depression.•Stattic or PD98059 attenuated the neurocardiac support benefit from rapamycin.•ERK and JAK/STAT3 pathways play an important role in the central rapamycin effects.

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关键词

CO,DCI,DWI,EBI,ERK,FOV,i.c.v.,i.p.,I/R,IVH,KATP,MRI,MRPK,mTOR,SAH,SbtO2,STAT3,SpO2,SV,3D,TE,TR,T2WI,VTI

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